Autoanticorps dans le lupus ????ryth????mateux syst????mique : profil et corr????lations cliniques

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• 作者：Haddouk ; S. ; Ben Ayed ; M. ; Baklouti ; S. ; Hachicha ; J. ; Bahloul ; Z. ; Masmoudi ; H.
• 关键词：Anti-dsDNA ; Antinucleosome ; Anti-SSA ; Anti-Sm ; Lupus
• 刊名：Pathologie Biologie
• 出版年：2005
• 出版时间：July, 2005
• 年：2005
• 卷：53
• 期：6
• 页码：311-317
• 全文大小：121 K

文摘

We have analysed the clinical features and autoantibody profile of 84 tunisian patients with newly diagnosed systemic lupus erythematosus (SLE). Antinuclear antibodies (ANA) were detected by an immunofluorescence method, anti-dsDNA and anti-cardiolipin (aCL) antibodies by ELISA, antinucleosome and anti-extractible nuclear antigens (or anti-ENA : anti-Sm, anti-RNP, anti-SSA and anti-SSB) by immunodot. The mean age of the patients was 29,9 years and the sex-ratio F/M was 6. The most common initial features were haematological (80 % ), rheumatological (78 % ) and cutaneous (75 % ) disorders. 59 % of the patients had glomerular nephropathy. ANA were detected in 97,6 % , antinucleosome in 78,6 % , anti-dsDNA in 75 % , anti-histones in 44 % , anti-Sm in 36,9 % , anti-RNP in 32,1 % , anti-SSA in 54,8 % and anti-SSB in 14,3 % of patients. IgG and IgM aCL were detected in 45 and 40 % of the patients respectively. The significant clinical associations were those of nephropathy and disease activity with anti-dsDNA and antinucleosome antibodies. Our results confirm the clinical polymorphism of SLE, the high frequency of antinucleosome antibodies at time of diagnosis and the predominance of anti-SSA among anti-ENA antibodies.