Pancreatic autoantibodies in Tunisian children with newly diagnosed type 1 diabetes

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• 作者：R. Fakhfakh ; S. Haddouk ; Y.B. Hadj Hamida ; T. Kamoun ; M.B. Ayed ; M. Hachicha ; H. Masmoudi
• 关键词：Type 1 diabetes ; Beta cells autoantibodies ; Antibody combination
• 刊名：Pathologie Biologie
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：56
• 期：3
• 页码：130-132
• 全文大小：150 K

文摘

We analyzed 86 children with newly diagnosed type 1 diabetes for antibodies to islet cells (ICA), glutamic acid decarboxylase (GADA), second-islet antigen (IA-2A), and insulin (IAA) in order to evaluate the prevalence of immune-mediated type 1 diabetes, as well as to recognize which autoantibody combination is more frequently associated with the disease. A positive result for one or more diabetes-related antibodies evaluated was found in 78 children (90.7 % ). With regard to single autoantibody testing, ICA were found to be positive in 49 patients (57 % ), GADA in 56 (65.1 % ), IA-2A in 37 (43 % ), and IAA in 43 (50 % ) patients. Combining the determination of at least two autoantibodies, GADA and/or IAA were better detectable than other antibody combination, being positive in 70 patients (81.4 % ). GADA and IA-2A represent also a useful screening combination; being positive in 65 patients (75.6 % ). Our data indicate that the vast majority of cases of type 1 diabetes in children may be considered as immune-mediated and that multiple autoantibody analysis improves identification of the disease.