Synthesis of 4-hydroxy-3-[(E)-2-(6-substituted-9H-purin-9-yl)vinyl]coumarins as lipoxygenase inhibitors

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• 作者：Michael G. Kallitsakis ; Dimitra J. Hadjipavlou-Litina ; Aikaterini Peperidou ; Konstantinos E. Litinas
• 关键词：4-Hydroxycoumarin ; Modified nucleosides ; Purines ; Lipoxygenase inhibitors
• 刊名：Tetrahedron Letters
• 出版年：15 January, 2014
• 年：2014
• 卷：55
• 期：3
• 页码：650-653
• 全文大小：487 K

文摘

The synthesis of 4-hydroxy-3-[(E)-2-(6-substituted-9H-purin-9-yl)vinyl] coumarins has been achieved from the reactions of 4-hydroxycoumarin with 2-(6-substituted-9H-purin-9-yl)acetaldehydes in DMF under heating. The new compounds showed significant lipoxygenase inhibitory activity (e.g., 6a: IC₅₀ = 6.25 渭M).