Teicoplanin use in adult patients with haematological malignancy: Exploring relationships between dose, trough concentrations, efficacy and nephrotoxicity
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- 作者：Catherine J. Byrnea ; Sean Eganb ; Jé ; rô ; me P. Fennellc ; Philomena O&rsquo ; Byrneb ; Helen Enrightd ; Evelyn Deasyb ; Sheila A. Rydera ; Deirdre M. D&rsquo ; Arcya ; ddarcy@tcd.ie" class="auth_mail" title="E-mail the corresponding author ; Johnny McHughd
- 关键词：Teicoplanin ; Haematological malignancy ; Therapeutic drug monitoring ; Pharmacokinetics ; Nephrotoxicity
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：46
- 期：4
- 页码：406-412
- 全文大小：485 K
文摘
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Acute myeloid leukaemia diagnosis was negatively associated with trough concentration.
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Higher loading doses are needed for adequate trough concentrations early in therapy.
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Suggested link between trough concentration and clinical efficacy.
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Teicoplanin was well tolerated renally.