Dietary docosahexaenoic acid reverses nonalcoholic steatohepatitis and fibrosis caused by conjugated linoleic acid supplementation in mice
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- 作者：Yuriko Adkinsa ; b ; Dawn M. Fedorb ; Bruce E. Mackeyc ; Jian Wud ; e ; f ; jian.wu@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; wujianucdmc@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Darshan S. Kelleya ; b ; darshan.kelley@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acca ; acetyl co-A carboxylase A ; Acox1 ; acyl coenzyme A oxidase 1 ; AT ; adipose tissue ; ALT ; alanine aminotransferase ; ARS ; Agricultural Research Service ; CLA ; conjugated linoleic acid ; Col1a1 ; procollagen type I alpha 1 ; CON ; control ; Cpt1a ; carnitine palmitoyltransferase 1a-liver ; DHA ; docosahexaenoic acid ; ECM ; extracellular matrix ; EPA ; eicosapentaenoic acid ; HOMA-IR ; homeostasis model assessment of insulin resistance ; H&E ; haematoxylin and eosin ; HSC ; hepatic stellate cells ; IR ; insulin resi
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：20
- 期：Complete
- 页码：443-452
- 全文大小：1728 K
文摘
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DHA feeding in mice to study reversal of NAFLD caused by CLA, a trans fatty acid.
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DHA decreased liver inflammation and fibrosis in CLA-induced NAFLD.
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DHA lowered liver triglycerides and level of enzyme associated with liver injury.
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Dietary DHA in humans may reverse CLA-induced adverse effects in the liver.