Tetraspanin 7 regulates sealing zone formation and the bone-resorbing activity of osteoclasts
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- 作者：Jun-Oh Kwon ; Yong Deok Lee ; Haemin Kim ; Min Kyung Kim ; Min-Kyoung Song ; Zang Hee Lee ; Hong-Hee Kim ; hhbkim@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tetraspanin 7 ; Podosome belt ; Sealing zone ; Src ; Pyk2 ; Microtubule
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：477
- 期：4
- 页码：1078-1084
- 全文大小：2103 K
文摘
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Tspan7 expression is up-regulated during osteoclastogenesis.
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Tspan7 regulates podosome belt organization in osteoclasts.
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Tspan7 is crucial for sealing zone formation and bone-resorption by osteoclasts.
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Src and Pyk2 phosphorylation and microtubule acetylation mediate Tspan7 function.