Silkworm ferritin 1 heavy chain homolog is involved in defense against bacterial infection through regulation of haemolymph iron homeostasis
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- 作者：Sohail Ahmed Othoa ; 1 ; Kangkang Chena ; 1 ; Yongdong Zhanga ; Peng Wanga ; Zhiqiang Lua ; b ; zhiqiang.lu@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ferritin ; Iron homeostasis ; Bacterial infection ; Defense ; Bombyx mori
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：152-158
- 全文大小：1760 K
文摘
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Pseudomonas aeruginosa or Staphylococcus aureus infection resulted in elevated iron levels in the hemolymph of larval silkworm.
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BmFer1 mRNA abundance was up-regulated in hemocytes after bacterial infection.
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BmFer1 reduced the plasma iron level after infection and limited the bacterial growth in the haemolymph.
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BmFer1 restricts iron access of the invading bacteria and blocks their growth as a defense strategy.