Cross-reactive antibody responses to the 2009 A/H1N1v influenza virus in the Italian population in the pre-pandemic period

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• 作者：Caterina Rizzo ; Maria Cristina Rota ; Antonino Bella ; Valeria Alfonsi ; Silvia Declich ; Maria Grazia Caporali ; Alessia Ranghiasci ; Giulia Lapini ; Simona Piccirella ; Stefania Salmaso ; Emanuele Montomoli
• 关键词：Pandemic influenza ; Seroprevalence ; Italy
• 刊名：Vaccine
• 出版年：2010
• 出版时间：30 April 2010
• 年：2010
• 卷：28
• 期：20
• 页码：3558-3562
• 全文大小：234 K

文摘

To assess in Italy the pre-pandemic susceptibility of the general population to the 2009 A/H1N1v influenza virus, 587 serum samples collected in 2004 were analyzed using haemagglutination-inhibition (HI), single-radial-haemolysis (SRH) and microneutralisation (MN) assays. Serum samples were stratified by age group, gender, and geographic area. Overall, using HI assay, the proportion of subjects showing antibodies cross-reacting with 2009 A/H1N1v virus at seroprotection level (≥1:40) was estimated to be 6.7 % , 12.4 % , and 22.4 % in individuals born between 2004 and 1949, 1948 and 1939, 1938 and 1909, respectively. With a HI antibody titre of ≥1:10, in the same birth cohort, the seroprotection levels were 13.5 % , 19.2 % , and 58.2 % , respectively. The results suggest that the Italian population was not fully naïf to the current pandemic virus and that the possible previous exposure and immune response increases with age.