- 作者：Young&ndash ; Joo Jin? ; So&ndash ; Yun Nah? ; Jin&ndash ; Woo Lee? ; jin@inha.ac.kr ; Jung&ndash ; Il Lee? ; Seok Jeong? ; Don Haeng Lee? ; &Dagger ; ; Young Soo Kim? ; Soon Gu Cho§ ; ; Yong Sun Jeon§ ;
- 关键词：Diagnosis ; Patient Management ; Early Detection ; Liver Cancer
- 刊名：Clinical Gastroenterology and Hepatology
- 出版年：2013
- 出版时间：February, 2013
- 年：2013
- 卷：11
- 期：2
- 页码：187-192
- 全文大小：700 K
Background & Aims
More information is needed on use of Primovist-enhanced magnetic resonance imaging (MRI) during initial staging analysis of patients with hepatocellular carcinoma (HCC) who are candidates for treatment with liver dynamic computed tomography (CT).Methods
We studied 104 patients who were initially diagnosed as Barcelona Clinic Liver Cancer (BCLC) stage 0 or A, without any other suspicious intrahepatic lesions, by liver dynamic CT from December 2009 to May 2012 at Inha University Hospital in Korea. We evaluated whether an addition of Primovist-enhanced MRI examination affected determination of BCLC stage, compared with liver dynamic CT.
Results
On the basis of CT analysis, the median tumor size was 2.3 cm, and 98 patients had HCCs that met the Milan criteria (94.2 % ). All 104 patients (100 % ) had nodular type HCC. Abnormal intrahepatic findings were detected by Primovist-enhanced MRI in 41 patients (39.4 % ). Eighteen patients (17.3 % ) had new HCCs, but 6 patients who were initially of BCLC stage A remained at this stage, despite increases in tumor numbers. Of the 104 patients, 31 (29.8 % ) and 73 (70.2 % ) had BCLC stage 0 and A HCC before Primovist-enhanced MRI, respectively, and 26 (25.0 % ), 71 (68.3 % ), and 7 (6.7 % ) patients had BCLC stages 0, A, and B HCC after Primovist-enhanced MRI, respectively. In 12 of the 104 patients (11.5 % ), BCLC stage changed from 0 to A (5/31, 16.1 % ) or from A to B (7/73, 9.6 % ).
Conclusions
Primovist-enhanced MRI can provide additional information that can lead to the detection of new intrahepatic HCC lesions during initial staging analyses of patients with BCLC stage 0 or A HCC by liver dynamic CT, despite the absence of other suspicious liver lesions.