Fingolimod (FTY720) improves hippocampal synaptic plasticity and memory deficit in rats following focal cerebral ischemia
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- 作者：Maryam Nazaria ; nazari_290@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Somaye Keshavarza ; keshavarso@sums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Ali Rafatia ; b ; arafati@sums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Mohammad Reza Namavarb ; namavarm@sums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Masoud Haghania ; b ; haghani55@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; haghani55@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Stroke ; FTY720 ; Fingolimod ; LTP ; Sphingosine-1-phosphate
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：95-102
- 全文大小：1635 K
文摘
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FTY720 improve impairments of memory following brain ischemia.
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FTY720 improve long term plasticity impairment induced by brain ischemia.
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Multiple injection of FTY720 improved memory performance after brain ischemia.
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Single injection was not sufficient to rescue neurological score after ischemia.