miR-206 functions as a novel cell cycle regulator and tumor suppressor in clear-cell renal cell carcinoma
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- 作者：Haibing Xiaoa ; b ; 1 ; Wei Xiaoc ; 1 ; Jing Caod ; Heng Lia ; b ; Wei Guana ; b ; Xiaolin Guoa ; b ; Ke Chena ; b ; Tao Zhenge ; Zhangqun Yea ; b ; Ji Wangf ; jiwang924@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Hua Xua ; b ; xuhua@mail.hust.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-206 ; ccRCC ; cell cycle ; tumor suppressor
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 April 2016
- 年：2016
- 卷：374
- 期：1
- 页码：107-116
- 全文大小：4519 K
文摘
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We reviewed and experimentally analyzed the currently available miRNA expression profiles data of ccRCC.
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miR-206 was identified as one of the most critical tumor-suppressing microRNAs in ccRCC.
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miR-206 inhibited ccRCC cell proliferation through inducing cell cycle arrest by directly targeting cell cycle related gene CDK4, CDK9 and CCND1.