Circulating CXCR5+CD4+ T cells assist in the survival and growth of primary diffuse large B cell lymphoma cells through interleukin 10 pathway

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• 作者：Zhanshan Cha^a ; ¹ ; Guangfang Qian^b ; ¹ ; Yan Zang^a ; Haihui Gu^a ; Yanyan Huang^a ; Lishuang Zhu^a ; Jinqi Li^a ; Yang Liu^a ; Xiaohua Tu^a ; Haihan Song^c ; Baohua Qian^a ; ^{qianbhl963@163.com}
• 关键词：Diffuse large B cell lymphoma ; Interleukin 10 ; Follicular helper T cell
• 刊名：Experimental Cell Research
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：350
• 期：1
• 页码：154-160
• 全文大小：1119 K
• 卷排序：350

文摘

We studied the role of the peripheral Tfh in DLBCL. Tfh were effective at promoting the proliferation of primary DLBCL tumor cells. Tfh were effective at inhibiting the apoptosis of primary DLBCL tumor cells. IL-10 secretion in Tfh was significant elevated in DLBCL. Neutralization of IL-10 compromised Tfh-mediated pro-tumor effects.