Target-catalyzed hairpin assembly and intramolecular/intermolecular co-reaction for signal amplified electrochemiluminescent detection of microRNA
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- 作者：Yan-Qing Yu ; Ji-Peng Wang ; Min Zhao ; Lin-Ru Hong ; Ya-Qin Chai ; Ruo Yuan ; yuanruo@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ying Zhuo ; yingzhuo@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Electrochemiluminescence ; Intramolecular co-reaction ; Intermolecular co-reaction ; Target recycle ; microRNA-21
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：442-450
- 全文大小：3971 K
文摘
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The thiosemicarbazide (TSC) was first chosen as coreactant to enhance the ECL signal.
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Target recycle and intra-/inter-molecular co-reaction were developed in this assay.
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The enzyme-free miR-21 ECL biosensor with a detection limit down to sub-femtomolar.