Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system
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- 作者：Chun Panga ; c ; 1 ; Zhiyong Zhenga ; 1 ; Liang Shia ; Yuchen Shengb ; Hai Weic ; Zhengtao Wanga ; Lili Jia ; lichenyue1307@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：APAP ; acetaminophen ; DILI ; drug-induced liver injury ; CA ; Caffeic acid ; ALT/AST ; alanine/aspartate aminotransferases ; MPO ; myeloperoxidase ; GSH ; glutathione ; ROS ; reactive oxygen species ; Nrf2 ; nuclear factor erythroid 2-related factor 2 ; HO-1 ; heme oxygenase 1 ; NQO1 ; NAD(P)H ; quinone oxidoreductase 1 ; ZnPP ; zinc protoporphyrin ; Dim ; diminutol ; Keap1 ; kelch-like ECH-associated protein-1 ; CYP ; cytochrome P450 ; NAPQI ; N-acetyl-p-benzoquinone imine ; NAC ; N-acetylcysteine ; H2DCFDA ; 2ʹ-7ʹ-Dichlorodih
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：236-246
- 全文大小：3023 K
文摘
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CA protects against APAP-induced hepatotoxicity.
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CA activates Keap1-Nrf2 antioxidative signaling pathway.
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HO1 and NQO1 are involved in the protection of CA against APAP-induced hepatotoxicity.
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CA interacts with the binding site of Nrf2 in keap1 protein.
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CA inhibits NAPQI-induced hepatotoxicity.