Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade
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- 作者：Haidong Tang1 ; 2 ; Yang Wang1 ; 2 ; Lukasz K. Chlewicki1 ; Yuan Zhang1 ; Jingya Guo3 ; Wei Liang3 ; Jieyi Wang4 ; Xiaoxiao Wang5 ; Yang-Xin Fu2 ; 3 ; yang-xin.fu@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：14 March 2016
- 年：2016
- 卷：29
- 期：3
- 页码：285-296
- 全文大小：2765 K
文摘
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Sufficient T cell infiltration is essential for response to PD-L1 blockade
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Targeting tumors with LIGHT creates a T cell-inflamed tumor microenvironment
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LIGHT overcomes tumor resistance to checkpoint blockade by increasing TILs
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This study provides a strategy to increase response rate to checkpoint blockade