Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
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- 作者：Anannya Bhattacharya1 ; 15 ; Ahmed N. Hegazy2 ; 3 ; 4 ; 15 ; Nikolaus Deigendesch5 ; Lindsay Kosack1 ; Jovana Cupovic6 ; Richard K. Kandasamy1 ; Andrea Hildebrandt1 ; Doron Merkler7 ; 8 ; Anja A. Kü ; hl9 ; Bojan Vilagos1 ; Christopher Schliehe1 ; Isabel Panse2 ; 3 ; Kseniya Khamina1 ; Hatoon Baazim1 ; Isabelle Arnold4 ; Lukas Flatz6 ; Haifeng C. Xu10 ; Philipp A. Lang10 ; 11 ; Alan Aderem12 ; Akinori Takaoka13 ; Giulio Superti-Furga1 ; 14 ; Jacques Colinge1 ; Burkhard Ludewig6 ; Max Lö ; hning2 ; 3 ; 16 ; Andreas Bergthaler1 ; 16 ; abergthaler@cemm.oeaw.ac.at" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2015
- 出版时间：17 November 2015
- 年：2015
- 卷：43
- 期：5
- 页码：974-986
- 全文大小：4315 K
文摘
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Viral infection leads to redox dysregulation including the downregulation of SOD1
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Sod1−/− mice exhibit aggravated viral hepatitis, which is rescued by antioxidants
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IFN-I signaling via STAT1 drives SOD1 downregulation and early liver damage
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Ablation of IFN-I signaling ameliorates viral hepatitis in Sod1−/− and WT mice