Plasma/Serum Leptin Levels in Patients with Systemic Lupus Erythematosus: A Meta-analysis

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• 作者：Hong-miao Li^a ; ^b ; Tian-ping Zhang^a ; ^b ; Rui-xue Leng^a ; ^b ; Xiang-pei Li^c ; Xiao-mei Li^c ; Hai-feng Pan^a ; ^b ; ^{panhaifeng1982@sina.com" class="auth_mail" title="E-mail the corresponding author} ; ^{panhaifeng1982@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Leptin ; Systemic lupus erythematosus ; SLE ; Meta-analysis ; Autoimmune disease
• 刊名：Archives of Medical Research
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：46
• 期：7
• 页码：551-556
• 全文大小：457 K

文摘

Currently published data regarding the relationship between plasma/serum leptin levels and systemic lupus erythematosus (SLE) are contradictory. To derive a more precise evaluation of this relationship, a meta-analysis was performed.

Methods

Published literature from PubMed, Embase and Cochrane Library were obtained. The study quality was assessed by the Newcastle–Ottawa scale. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effects or random-effect model analysis. Heterogeneity among studies was estimated using the Cochran Q and I² statistics.

Results

A total of 11 studies including 868 SLE patients and 591 controls were finally included in the meta-analysis. No significant differences in plasma/serum leptin levels was found between SLE patients and healthy controls when all studies were pooled into the meta-analysis (pooled SMD = 0.269, 95% CI = −0.188 to 0.726). However, subgroup analyses showed that SLE patients from an Asian population, age ≥40 years and BMI <25 had higher plasma/serum leptin levels when compared with controls.

Conclusion

There is no significant difference in plasma/serum leptin levels between the entire group of SLE patients and controls. However, plasma/serum leptin levels are significantly higher in the subgroup of SLE patients from an Asian population ≥40 years of age and with a BMI <25.