Monodisperse calcium carbonate nanospheres (~ 200 nm) encapsulated with doxorubicin was prepared.
The preparation of CaCO3 nanospheres and the encapsulation of doxorubicin were facilitated in one step.
Our strategy is a facile precipitation method for encapsulation of anticancer drug in water without any other organic agent.
The release of doxorubicin from the nanospheres is pH responsive.