Three new lignan glucosides from the roots of Scutellaria baicalensis

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• 作者：Hailin Long ; Haijing Zhang ; Anjun Deng ; Lin Ma ; Lianqiu Wu ; ^{wlq@imm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Zhihong Li ; Zhihui Zhang ; Wenjie Wang ; Jiandong Jiang ; Hailin Qin ; ^{qinhailin@imm.ac.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Scutellaria baicalensis ; Roots ; Labiatae ; Lignan glucoside ; Baicalensinosides A&ndash ; C ; 3 ; 4-Dibenzyltetrahydrofuran ; Osteoprotegerin-activating activity ; Anti-osteoporotic activity
• 刊名：Acta Pharmaceutica Sinica B
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：6
• 期：3
• 页码：229-233
• 全文大小：380 K

文摘

Three new lignan glucosides, baicalensinosides A–C (1–3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofuran-type lignan glycoside with a mono-hydroxyl substitution at the 7′-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin (OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 μmol/L, compounds 1–3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively.