Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression
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- 作者：Jianhua Yua ; 1 ; Weiguang Zhangb ; 1 ; Rongguo Zhangc ; Guixing Jiangd ; Haijun Tanga ; Xinxian Ruana ; Peitu Rena ; Baochun Lua ; sygd_lbc@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：H2 ; molecular hydrogen ; H/R ; hypoxia/reoxygenation ; I/R ; ischemia/reperfusion ; ROS ; reactive oxygen species ; Nrf2 ; NF-E2-related factor 2 ; HRM ; hydrogen-rich medium ; HRS ; hydrogen-rich saline ; NS ; normal saline ; BCL2 ; B-cell CLL/lymphoma 2 ; BAX ; BCL2-associated X protein ; HO-1 ; heme oxygenase 1 ; CK7 ; keratin 7 ; CK19 ; keratin 19 ; AQP1 ; aquaporin 1 ; EPCAM ; epithelial cell adhesion molecule ; Icam1 ; intercellular adhesion molecule 1 ; ALB ; albumin ; G6PC ; glucose-6-phosphatase ; Nqo1 ; nicotinamide aden
- 刊名：Toxicology Letters
- 出版年：2015
- 出版时间：4 November 2015
- 年：2015
- 卷：238
- 期：3
- 页码：11-19
- 全文大小：2529 K
文摘
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H2 ameliorates cholangiocytes H/R injury in vitro.
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Nrf2 signaling is activated in cholangiocytes after exposed to H2.
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H2 could not protect Nrf2-silenced cholangiocytes from H/R injury.
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H2 protects cholangiocytes from I/R injury through in vivo.