Sensitive analysis and pharmacokinetic study of the isomers paeoniflorin and albiflorin after oral administration of Total Glucosides Of White Paeony Capsule in rats
详细信息 查看全文
- 作者：Fei Feia ; 1 ; Hailing Yangb ; 1 ; Ying Penga ; Pei Wanga ; Shuyao Wangc ; Yuqing Zhaoa ; Jingqiu Huanga ; Xiaoyi Yua ; Siqi Fenga ; Runbin Suna ; Na Yanga ; Hongbo Wangd ; Jiye Aaa ; jiyea@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; jiye_2005@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Guangji Wanga ; guangjiwang@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：TGP ; Total Glucosides Of White Paeony Capsule ; ESI ; electrospray ionization ; MRM ; multiple reaction monitoring ; IS ; internal standard ; LLOQ ; lower limits of quantification ; QC ; quality control ; LLE ; liquid&ndash ; liquid extraction
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：1022
- 期：Complete
- 页码：30-37
- 全文大小：1255 K
文摘
- •
A LC–MS/MS method was established to quantify paeoniflorin and albiflorin simultaneously in various bio-samples of rats.
- •
Pharmacokinetic properties of paeoniflorin and albiflorin were evaluated after oral administration of TGP.
- •
Paeoniflorin and albiflorin had high exposure in immune tissues, which could facilitate immuno-regulatory activities of TGP.