IDH mutation and MGMT promoter methylation are associated with the pseudoprogression and improved prognosis of glioblastoma multiforme patients who have undergone concurrent and adjuvant temozolomide-based chemoradiotherapy
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- 作者：Hailong Li ; M.D.a ; Jiye Li ; M.D.b ; Gang Cheng ; M.D.a ; Jianning Zhang ; M.D.a ; Xuezhen Li ; M.D.c ; hjzyysw@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glioblastoma ; Chemotherapy ; Pseudoprogression ; Molecular genetics ; IDH mutation ; MGMT
- 刊名：Clinical Neurology and Neurosurgery
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：31-36
- 全文大小：1512 K
文摘
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MGMT promoter methylation and IDH1 mutation highly correlated with pseudoprogression.
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MGMT promoter methylation and IDH1 mutation cumulatively influenced the overall survival.
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MGMT promoter methylation, IDH1 mutation and psPD predicted better prognosis.