Nodular glomerulosclerosis and renin angiotensin system in Chinese patients with type 2 diabetes
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- 作者：Min Wanga ; b ; Xiaoxi Zhanga ; b ; Xinnan Songb ; Xia Zoua ; b ; Weijie Wua ; b ; Yanchao Wanga ; b ; Bingjie Lina ; b ; Rong Lib ; c ; Fang Hud ; Hailu Zhaoa ; b ; zhaohailu9@126.com" class="auth_mail" title="E-mail the corresponding author ; zhaohailu@glmc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; zhaohailu@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Type 2 diabetes ; Angiotensin I converting enzyme 2 ; Hypertension ; Nodular glomerulosclerosis ; Renin-angiotensin system
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：427
- 期：Complete
- 页码：92-100
- 全文大小：2616 K
文摘
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This study reveals an association of RAS components and NGS in patients and autopsy cases with type 2 diabetes.
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The patients with ACE D or AGT T alleles might have reduced eGFR and macroalbuminuria.
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Difference in the immunoreactivity of ACE2 may contribute to the development of nodular glomerulosclerosis.