Stepped MSAll Relied Transition (SMART): An approach to rapidly determine optimal multiple reaction monitoring mass spectrometry parameters for small molecules
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- 作者：Hui Ye1 ; Lin Zhu1 ; Lin Wang ; Huiying Liu ; Jun Zhang ; Mengqiu Wu ; Guangji Wang ; Haiping Hao ; hhp_770505@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Stepped MSAll ; Stepped MSAll Relied Transition (SMART) ; Multiple reaction monitoring (MRM) ; Q-TOF ; Quantitative analysis ; Complex mixture
- 刊名：Analytica Chimica Acta
- 出版年：2016
- 出版时间：11 February 2016
- 年：2016
- 卷：907
- 期：Complete
- 页码：60-68
- 全文大小：1284 K
文摘
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A Stepped MSAll-Relied Transition (SMART) approach was developed on Q-TOF.
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The SMART approach can predict optimal MS parameters in high throughput.
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The SMART-predicted parameters can be directly applied to MRM quantitation on QQQ.
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The SMART approach was validated by analysis of standards and complex mixture.
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The SMART approach was applied to plasma pharmacokinetics of herbal medicine.