Skin tumor development after UV irradiation and photodynamic therapy is unaffected by short-term pretreatment with 5-fluorouracil, imiquimod and calcipotriol. An experimental hairless mouse study
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- 作者：Christiane Bay ; christiane.marie.bay@regionh.dk" class="auth_mail" title="E-mail the corresponding author ; Katrine Togsverd-Bo ; Catharina M. Lerche ; Merete Haedersdal
- 关键词：Antineoplastic drugs ; Hairless mice ; Pretreatment ; Photodynamic therapy ; Protoporphyrin IX
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：154
- 期：Complete
- 页码：34-39
- 全文大小：658 K
文摘
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Pretreatment with antineoplastic and pro-differentiating agents may enhance PDT response.
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Three applications of calcipotriol, 5FU and imiquimod creams were applied before MAL-PDT.
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MAL-PDT significantly delayed UV-induced skin tumor onset in hairless mice.
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Tumor development was not further delayed by pretreatment compared to PDT alone.
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Long-term topical pharmacological pretreatment may hold potential to enhance PDT.