Enhanced photostability of ICG in close proximity to gold colloids
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- 作者：Geddes ; Chris D. ; Cao ; Haishi ; Lakowicz ; Joseph R.
- 关键词：Fluorescence ; Photostability ; Indocyanine green ; Gold colloids
- 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- 出版年：2003
- 出版时间：September, 2003
- 年：2003
- 卷：59
- 期：11
- 页码：2611-2617
- 全文大小：370 K
文摘
Photobleaching of fluorophores frequently limits their detectability or observation time. We examined Indocyanine green (ICG) which is widely used in medical testing and is highly unstable. We showed that spatial localization of ICG near metallic gold colloids resulted in increased photostability. This suggests the use of fluorophore–metal conjugates in situations adversely affected by photobleaching.