Electrochemically sensitive determination of dopamine and uric acid based on poly (beryllon II)/nanowires-LaPO₄ modified carbon paste electrode

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• 作者：Yuanzhen Zhou ; ^{zyz1289@126.com} ; ^{zhouyuanzhen@xauat.edu.cn}Author Vitae ; Haiyan ZhangAuthor Vitae ; Jiang ZhangAuthor Vitae ; Ting LiuAuthor Vitae ; Weimin TangAuthor Vitae
• 关键词：Electrochemical sensor ; Beryllon II ; LaPO4 nanowires ; Dopamine ; Uric acid
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：182
• 期：Complete
• 页码：610-617
• 全文大小：1452 K

文摘

A sensitive and selective electrochemical sensor based on poly (beryllon II)/nanowires-LaPO₄ composite film modified carbon paste electrodes (CPE) was successfully constructed and used to study the catalytic oxidation of dopamine (DA) and uric acid (UA). Scanning electron microscope (SEM) and electrochemical techniques were used to characterize the properties of the modified electrode. The sensor exhibits strong electrochemical catalytic activity toward the oxidation of DA and UA thanks to synergic effect of poly (beryllon II)/nanowires-LaPO₄ in 0.1 M phosphate buffer solution (pH 7.0). By using of differential pulse voltammetry (DPV), linear calibration curves are obtained as 0.10-31.60 and 39.38-403.28 ¦ÌM for DA and 0.82-682.94 ¦ÌM for UA. The detection limits are 0.03 ¦ÌM and 0.23 ¦ÌM for DA and UA, respectively. Moreover, this electrochemical sensor was applied to the simultaneous detection of DA and UA with high sensitivity and selectivity. Furthermore, the modified electrode displayed high reproducibility and stability for these species determination. Thus, the proposed sensor could be advantageously employed for the determination of DA in real pharmaceutical formulations.