IL-17A promotes microglial activation and neuroinflammation in mouse models of intracerebral haemorrhage
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- 作者：Anyong Yub ; 1 ; Haizhen Duanb ; 1 ; Tianxi Zhangb ; Yong Panb ; Zhi Koub ; Xiaojun Zhangb ; Yuanlan Lub ; Song Wangb ; Zhao Yanga ; yangzhao5140@sohu.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：IL-17A ; Microglia ; Neuroinflammation ; ICH
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：151-157
- 全文大小：1686 K
文摘
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IL-17A Ab prevented ICH-induced cytokine expression and downstream signaling molecules.
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IL-17A Ab attenuated microglial activation.
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IL-17A Ab significantly reduced brain water content and improved neurological function of ICH mice.
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IL-17A Ab might also provide a promising therapeutic strategy in ICH.