A comparison of the cellular actions of polaprezinc (zinc-l-carnosine) and ZnCl₂

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• 作者：Hakaru Seo ; Ikuko Ogata-Ikeda ; Shiro Ishida ; Yoshiro Okano ; Yasuo Oyama
• 关键词：Polaprezinc ; Zinc-l-carnosine ; Zinc supplement ; Zinc chloride ; Intracellular Zn2  ; + ; Nonprotein thiol
• 刊名：Life Sciences
• 出版年：2012
• 出版时间：27 June, 2012
• 年：2012
• 卷：90
• 期：25-26
• 页码：1015-1019
• 全文大小：568 K

文摘

Aims

Zinc supplementation has been proven to be beneficial for the prevention of some health problems. Many zinc supplements are used for medical and nutritional purposes. However, it is difficult to distinguish between them in terms of their cellular actions. We compared the cellular actions of polaprezinc (zinc-l-carnosine) with those of ZnCl₂ in order to determine whether polaprezinc has greater zinc-related actions than ZnCl₂.

Main methods

Cellular actions of polaprezinc and ZnCl₂ were estimated by flow-cytometric techniques with appropriate fluorescent probes in rat thymocytes.

Key findings

Both agents had almost equal stimulatory effects on the intracellular Zn^2 + level and cellular level of nonprotein thiol in a similar concentration-dependent manner. However, the increase in cell lethality caused by ZnCl₂ under severe oxidative stress was significantly greater than that caused by polaprezinc.

Significance

There are various zinc supplements, for example, zinc gluconate, zinc picolinate, and zinc methionine. However, the differences in their cellular actions have not been elucidated to date. Such studies could distinguish between zinc supplements.