Bone marrow fat unsaturation in young adults is not affected by present or childhood obesity, but increases with age: A pilot study

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• 作者：Ville Huovinen^a ; ^b ; Heli Viljakainen^c ; Antti Hakkarainen^d ; Tero Saukkonen^c ; ^e ; Sanna Toiviainen-Salo^d ; Nina Lundbom^d ; Jesper Lundbom^d ; ^f ; ^g ; Outi Mä ; kitie^c ; ^h ; ⁱ ; ^j ; ^{outi.makitie@helsinki.fi" class="auth_mail" title="E-mail the corresponding author}
• 关键词：BMI ; Body mass index ; BMD ; Bone mineral density ; BMF ; Bone marrow fat ; UI ; Unsaturation index ; 1H-MRS ; Magnetic resonance proton spectroscopy ; PA ; Physical activity ; BMR ; Basal metabolic rate ; Insulin ; Fasting serum insulin ; Glucose ; Fasting plasma glucose ; HB ; Harris-Benedict ; HOMA ; Homeostasis Model Assessment of Insulin Resistance (HOMA-IR2) index ; DXA ; Dual-energy X-ray absorptiometry ; TE ; Echo time
• 刊名：Metabolism
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：64
• 期：11
• 页码：1574-1581
• 全文大小：407 K

文摘

Obesity increases bone marrow fat (BMF) content. The association between early obesity and bone marrow fatty acid composition is unknown. We measured BMF unsaturation index (UI) in normal-weight and overweight young adults with a known weight status in early childhood and tested the relationship between BMF UI and exercise history, glycemic state, and other clinical characteristics.

Methods

The study included 18 normal-weight (BMI < 25 kg/m²; 2 males, 16 females) and 17 overweight (BMI ≥ 25 kg/m²; 9 males, 8 females) young adults aged 15–27 years. BMF UI was assessed with magnetic resonance proton spectroscopy optimized to reduce water interference. Exercise information was obtained with a pedometer accompanied with the history of recent physical activity. Blood samples (insulin, glucose, HbA1c) and body characteristics (BMI, waist-to-hip ratio, body fat composition) were assessed.

Results

BMF UI was not affected by obesity at the time of study or before age 7 years. BMF UI increased with age in normal-weight and overweight subjects (R = 0.408, p = 0.015) but did not associate with gender, physical activity or body fat composition; a suggestive association was observed with glucose (R = − 0.289, p = 0.10).

Conclusions

The association of BMF UI with age in early adulthood may represent normal maturation of bone marrow. There was a trend toward an association with blood glucose, warranting further studies.