Phloridzin: Biosynthesis, distribution and physiological relevance in plants

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• 作者：Christian Gosch ; Heidi Halbwirth ; Karl Stich
• 关键词：Malus × ; domestica ; Flavonoid biosynthesis ; Plant physiology ; Polyphenol ; Dihydrochalcone ; Phloridzin ; NADPH-dependent dehydrogenase ; Chalcone synthase ; UDP-glucose ; phloretin 2′ ; -O-glycosyltransferase
• 刊名：Phytochemistry
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：71
• 期：8-9
• 页码：838-843
• 全文大小：274 K

文摘

The phenolic compound phloridzin (phloretin 2′-O-glucoside, phlorizin, phlorrhizin, phlorhizin or phlorizoside) is a prominent member of the chemical class of dihydrochalcones, which are phenylpropanoids. The apple tree (Malus sp.) accumulates high amounts of phloridzin, whereas few other species contain this compound only in low amounts. Additionally, Malus sp. show a species- and tissue-specific distribution of phloridzin and its derivatives. Whereas the physiological role of phloridzin in planta is not fully understood, the effect on human health – especially diabetes – and membrane permeability is well documented. The biosynthesis of phloridzin was investigated only recently with recombinant enzymes and plant protein extracts and involved a NADPH-dependent dehydrogenase, chalcone synthase and UDP-glucose:phloretin 2′-O-glycosyltransferase.