Exploration of electrostatic interaction in the hydrophobic pocket of lysozyme: Importance of ligand-induced perturbation of the secondary structure on the mode of binding of exogenous ligand and possible consequences
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- 作者：Sudipta Panja ; Mintu Halder ; mintu@chem.iitkgp.ernet.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Weak molecular interaction ; Pocket charge ; Secondary structure alteration ; Entropy enthalpy compensation (EEC) ; Perturbation by ligand ; Exogenous ligand
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：253-265
- 全文大小：1856 K
文摘
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An interesting example of electrostatic binding in the hydrophobic pocket of lysozyme
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Binding of exogenous tartrazine leads to considerable loss of the secondary structure.
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Enthalpy-entropy compensation (EEC) as a marker of less perturbed after ligand binding
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Poor EEC could ultimately lead to ligand-induced protein structure perturbation.
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The hydrophobic binding cavity is estimated to carry some net positive charge.