Phytotoxic halimanes isolated from Baccharis salicifolia (Ruiz & Pad.) Pers.

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• 作者：Soledad del Corral^a ; Silvia L. Cuffini^b ; ^c ; ¹ ; Simone G. Cardoso^b ; Adailton J. Bortoluzzid^d ; Sara M. Palacios^a ; ¹ ; ^{sarapalacios@ucc.edu.ar}
• 关键词：Baccharis salicifolia ; Halimane ; Germination inhibition ; Growth inhibition ; Panicum miliaceum ; Raphanus sativus
• 刊名：Phytochemistry Letters
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：5
• 期：2
• 页码：280-283
• 全文大小：339 K

文摘

From the EtOH extract of the medicinal native plant, Baccharis salicifolia, two novel halimane-type diterpenoids, salicifolic acid (1) and 5-hydroxy-6-hydro-salicifolic acid (2) together with the known compounds sakuranetin (3), apigenin (4) and scopoletin (5) were bioguided isolated against Panicum miliaceum (monocotyledonous). The structures of 1 and 2 were established by extensive spectroscopic analyses. The effective concentration for 50 % inhibition of germination (ECg₅₀) and the root (ECr₅₀) and shoot (ECs₅₀) elongations was determined for 1-5 against P. miliaceum and Raphanus sativus (dicotyledonous). Compound 2 was the most active in the inhibition of germination of P. miliaceum (ECg₅₀ = 1 mM), followed by 1, 5 and 3, although 1 was the most effective in regulating the growth of P. miliaceum seedlings, with a ECr₅₀ and ECs₅₀ values of 1.8 and 6.6 mM, respectively. Compounds 1 and 3 were the only samples capable of inhibiting the germination of R. sativus, while seedling development was affected by 1, 2, and 3 with different effectiveness.