Substrate specificity of the CYC2 enzyme from Kitasatospora griseola: production of sclarene, biformene, and novel bicyclic diterpenes by the enzymatic reactions of labdane- and halimane-type diterpene diphosphates
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- 作者：Chiaki Nakano ; Tsutomu Hoshino ; Tsutomu Sato ; Tomonobu Toyomasu ; Tohru Dairi ; Takeshi Sassa
- 关键词：Diterpenes ; Enzymatic synthesis ; Sclarene ; Biformene ; Unnatural natural product
- 刊名：Tetrahedron Letters
- 出版年：2010
- 出版时间：6 January 2010
- 年：2010
- 卷：51
- 期：1
- 页码：125-128
- 全文大小：242 K
文摘
The enzymatic reaction of copalyl diphosphate (CDP), ent-CDP, syn-CDP, and tuberculosinyl diphosphate with the CYC2 enzyme from Kitasatospora griseola afforded sclarene, biformene, and novel diterpenes having a buta-1,3-diene moiety in the side chain. The substrate specificity of the CYC2 is discussed.