Cytotoxic terpenoids from Nardophyllum bryoides

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• 作者：Marianela Sá ; nchez ; Marcia Mazzuca ; Marí ; a José ; Veloso ; Lucí ; a R. Ferná ; ndez ; Gastó ; n Siless ; Lydia Puricelli ; Jorge A. Palermo
• 关键词：Nardophyllum bryoides ; Astereae ; Terpenoid ; Seco-chiliolidic acid ; Seco-ent-halimane
• 刊名：Phytochemistry
• 出版年：2010
• 出版时间：August 2010
• 年：2010
• 卷：71
• 期：11-12
• 页码：1395-1399
• 全文大小：252 K

文摘

The investigation of the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides collected in the province of Chubut, Argentina, yielded eleven terpenoids. These include: three seco-ent-halimane diterpenoids (1–3), two ent-halimanes (4–5) and six pentacyclic oleanane and ursane triterpenoids (6–11). Four of these compounds (2, 6, 8 and 11) are hitherto unknown, while two others (1 and 4) have been previously reported but only as synthetic products. Several of these compounds showed moderate cytotoxicity against a human pancreatic adenocarcinoma cell line while compounds 4 and 5 were active at micromolar concentrations. The main component, seco-chiliolidic acid (1), could be isolated from this extract in large amounts, turning N. bryoides into a sustainable source of this bioactive compound.