Agelasines O-U, new diterpene alkaloids with a 9-N-methyladenine unit from a marine sponge Agelas sp.

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• 作者：Takaaki Kubota ; Takahiro Iwai ; Azusa Takahashi-Nakaguchi ; Jane Fromont ; Tohru Gonoi ; Jun'ichi Kobayashi
• 关键词：Marine sponge ; Agelas sp. ; Diterpene alkaloid ; Bromopyrrole alkaloid ; Agelasines O&ndash ; U ; Antimicrobial activity
• 刊名：Tetrahedron
• 出版年：2012
• 出版时间：25 November, 2012
• 年：2012
• 卷：68
• 期：47
• 页码：9738-9744
• 全文大小：884 K

文摘

New diterpene alkaloids, agelasines O-U (1-7), have been isolated from an Okinawan marine sponge Agelas sp. The gloss structures and relative stereochemistries of 1-7 were elucidated from the spectroscopic data. Agelasines O-R (1-4) were the third examples of diterpene alkaloid with a 9-N-methyladenine and a pyrrole units. Agelasine O (1) has a halimane skeleton, while agelasines P-R (2-4) have a clerodane skeleton. Agelasines S-U (5-7) were new diterpene alkaloids with a 9-N-methyladenine unit consisting of a halimane skeleton, a labdane skeleton, and a clerodane skeleton, respectively. Agelasines O-R (1-4) and T (6) showed antimicrobial activities against several bacteria and fungi.