Diterpenoids from the twigs and leaves of Croton caudatus var. tomentosus

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• 作者：Jin-Tong Song^a ; Yang Han^a ; Xiao-Ling Wang^b ; Tao Shen^a ; Hong-Xiang Lou^a ; Xiao-Ning Wang^a ; ^{wangxn@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ent-15 ; 16-epoxyhalim-5(10) ; 13(16) ; 14-trien-18-carboxylic acid (PubChem CID ; 11404306) ; Margocin (PubChem CID ; 21632833) ; 15-hydroxy-7-oxoabieta-8 ; 11 ; 13-triene (PubChem CID ; 128740) ; 5-epi-eudesm-4(15)-ene-1β ; 6β-diol (PubChem CID ; 11746695) ; Cisplatin (PubChem CID ; 5702198) ; Doxorubicin (PubChem CID ; 31703)
• 刊名：Fitoterapia
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：107
• 期：Complete
• 页码：54-59
• 全文大小：501 K

文摘

One new 9,10-seco-abietane derivative, crotontomentosin A (1), four new abietane-type diterpenoids, crotontomentosins B–E (2–5), one new ent-halimane-type diterpenoid, crotontomentosin F (6), along with five known diterpenoids (7–11) and one known sesquiterpenoid (12) were obtained from the twigs and leaves of Croton caudatus Geisel. var. tomentosus Hook. The structures of the compounds were established on the basis of extensive spectroscopic data. Compounds 1–4 and 11 exhibited moderate to weak inhibitory activity against the proliferation of the Hela, Hep G2, MDA-MB-231, or A549 cell lines selectively.