The serotonergic hallucinogen 5-methoxy-N,N-dimethyltryptamine disrupts cortical activity in a regionally-selective manner via 5-HT1A and 5-HT2A receptors
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- 作者：Maurizio S. Rigaa ; b ; c ; Analia Bortolozzia ; b ; c ; Letizia Campaa ; b ; c ; Francesc Artigasa ; b ; c ; Pau Celadaa ; b ; c ; pau.celada@iibb.csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Prefrontal cortex ; Sensorial cortical areas ; Visual cortex ; Hallucinogens ; 5-HT receptors ; Oscillatory activity
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：370-378
- 全文大小：2187 K
文摘
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5-MeO-DMT alters cortical activity in primary sensory areas (Au1, S1, V1) and PFC.
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5-MeO-DMT disrupts oscillatory activity in visual cortex through 5-HT1A receptors.
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5-MeO-DMT disrupt oscillatory activity in PFC via 5-HT1A and 5-HT2A receptors.
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Antipsychotic drugs restore oscillatory activity after 5-MeO-DMT treatment.
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5-MeO-DMT reduces 5-HT release in PFC mainly through 5-HT1A receptors.