Classic hallucinogens in the treatment of addictions
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- 作者：Michael P. Bogenschutza ; mbogenschutz@salud.unm.edu" class="auth_mail" title="E-mail the corresponding author ; Matthew W. Johnsonb ; mwj@jhu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：5HT ; 5-hydroxytryptamine (= serotonin) ; ASI ; Addiction Severity Index ; BDNF ; brain-derived neurotrophic factor ; BOLD ; blood oxygen level-dependent ; DMT ; dimethyltryptamine ; DOI ; 2 ; 5-dimethoxy-4-iodoamphetamine ; DOM ; 2 ; 5-dimethoxy-4-methylamphetamine ; DPT ; N-N-dipropyltryptamine ; FDA ; Food and Drug Administration ; GDNF ; glial cell line-derived neurotrophic factor ; LSD ; lysergic acid diethylamide ; mRNA ; messenger ribonucleic acid ; NAC ; Native American Church ; PTSD ; post-traumatic stress disorder
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：4 January 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：250-258
- 全文大小：462 K
文摘
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We review the use of classic hallucinogens in the treatment of addiction.
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Controlled trials support the efficacy of high-dose LSD for alcoholism.
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Pilot studies of psilocybin for nicotine and alcohol dependence suggested benefit.
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Definitive studies of efficacy and therapeutic mechanisms remain to be done.