Classical hallucinogens and neuroimaging: A systematic review of human studies: Hallucinogens and neuroimaging

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• 作者：Rafael G. dos Santos ; PhD^a ; ^{banisteria@gmail.com} ; Flá ; via L. Osó ; rio ; PhD^a ; ^b ; José ; Alexandre S. Crippa ; MD ; PhD^a ; ^b ; Jaime E.C. Hallak ; MD ; PhD^a ; ^b
• 关键词：Hallucinogens ; Ayahuasca ; DMT ; Psilocybin ; Mescaline ; LSD ; Neuroimaging ; SPECT ; PET ; fMRI ; Default mode network
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：71
• 期：Complete
• 页码：715-728
• 全文大小：995 K
• 卷排序：71

文摘

Serotonergic hallucinogens induce profound changes in the human mind/brain. Hallucinogenic effects are produced by agonism at cortical 5-HT2A receptors. 5-HT2A receptors modulate brain activity in fronto-temporo-parieto-occipital areas. Agonism at 5-HT2A receptor alters perceptions, memory, emotion, and self-awareness. Serotonergic hallucinogens have anxiolytic, antidepressive and antiaddictive effects.