A practical synthesis of 2-aminobenzothiazoles via the tandem reactions of 2-haloanilines with isothiocyanates catalyzed by immobilization of copper in MCM-41

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• 作者：Ruian Xiao¹ ; Wenyan Hao¹ ; Jinting Ai¹ ; Ming-Zhong Cai ; ^{caimzhong@163.com}
• 关键词：Immobilized copper catalyst ; 2-Aminobenzothiazole ; Tandem reaction ; Functionalized MCM-41 ; Heterogeneous catalysis
• 刊名：Journal of Organometallic Chemistry
• 出版年：2012
• 出版时间：15 May, 2012
• 年：2012
• 卷：705
• 期：Complete
• 页码：44-50
• 全文大小：252 K

文摘

The heterogeneous tandem reactions of 2-haloanilines with isothiocyanates were achieved in DMSO using Et₃N as base at 80 ¡ãC in the presence of a 3-(2-aminoethylamino)propyl-functionalized MCM-41-immobilized copper(II) complex [MCM-41-2N-CuSO₄], yielding a variety of 2-aminobenzothiazoles in good to excellent yields. This heterogeneous copper catalyst exhibited higher activity than CuSO₄ and can be recovered and recycled by a simple filtration of the reaction solution and used for at least 10 consecutive trials without any decreases in activity.