Optimized synthesis of a pentafluoro-gem-diol and conversion to a CF2Br-glucopyranose through trifluoroacetate-release and halogenation
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- 作者：Robert A. Hazlitta ; b ; Jinu P. Johna ; Que-Lynn Tranb ; David A. Colbya ; b ; dacolby@olemiss.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fluorine ; Aldol reaction ; Halogenation ; Glycoside ; Pyranose
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：27 April 2016
- 年：2016
- 卷：57
- 期：17
- 页码：1906-1908
- 全文大小：686 K
文摘
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A complex glucose-derived pentafluoro-gem-diol is synthesized.
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A tandem trifluoroacetate-release halogenation/cyclization is executed.
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The first synthesis of a CF2Br-glucopyranose is completed.