Potent transglutaminase inhibitors, aryl β-aminoethyl ketones
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- 作者：Shoichiro Ozaki ; Etsuko Ebisui ; Kozo Hamada ; Jun-Ichi Goto ; Akinobu Z. Suzuki ; Akiko Terauchi ; Katsuhiko Mikoshiba
- 关键词：Transglutaminase inhibitor ; Protein cross-link inhibitor ; Alzheimer’ ; s disease ; Huntington’ ; s disease ; Parkinson’ ; s disease ; Celiac disease
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2010
- 出版时间：1 February 2010
- 年：2010
- 卷：20
- 期：3
- 页码：1141-1144
- 全文大小：248 K
文摘
Aryl β-aminoethyl ketones were discovered as potent inhibitors of tissue transglutaminase. Heteroaryl-like thiophene groups and N-benzyl N-t-butyl aminoethyl group are critical to the strong inhibitory activity of aryl β-aminoethyl ketones.