Long-Term Outcome of Incomplete Revascularization After Percutaneous Coronary Intervention in SCAAR (Swedish Coronary Angiography and Angioplasty Registry)

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• 作者：Kristina Hambraeus ; MD ; PhD^a ; ^b ; ^{Kristina.hambraeus@ltdalarna.se" class="auth_mail" title="E-mail the corresponding author} ; Karin Jensevik ; MSc^c ; Bo Lagerqvist ; MD ; PhD^b ; ^c ; Bertil Lindahl ; MD ; PhD^b ; ^c ; Roland Carlsson ; MD ; PhD^d ; Ramin Farzaneh-Far ; MD^e ; Thomas Kellerth ; MD^f ; Elmir Omerovic ; MD ; PhD^g ; Gregg Stone ; MD ; PhD^h ; Christoph Varenhorst ; MD ; PhD^b ; ^c ; Stefan James ; MD ; PhD^b ; ^c
• 关键词：incomplete revascularization ; multivessel disease ; PCI ; registry study
• 刊名：JACC: Cardiovascular Interventions
• 出版年：2016
• 出版时间：8 February 2016
• 年：2016
• 卷：9
• 期：3
• 页码：207-215
• 全文大小：434 K

文摘

The aim of this study was to describe current practice regarding completeness of revascularization in patients with multivessel disease undergoing percutaneous coronary intervention (PCI) and to investigate the association of incomplete revascularization (IR) with death, repeat revascularization, and myocardial infarction (MI) in a large nationwide registry.

Background

The benefits of multivessel PCI are controversial.

Methods

Between 2006 and 2010 we identified 23,342 patients with multivessel disease in the SCAAR (Swedish Coronary Angiography and Angioplasty Registry) and merged data with official Swedish health data registries. IR was defined as any nontreated significant (60%) stenosis in a coronary artery supplying >10% of the myocardium.

Results

Patients with IR (n = 15,165) were older, had more extensive coronary disease, and more often had ST-segment elevation MI at presentation than those with complete revascularization (CR) (n = 8,177). All-cause 1-year mortality, MI, and repeat revascularization were higher in IR than CR: 7.1% versus 3.8%, 10.4% versus 6.0%, and 20.5% versus 8.5%, respectively. Propensity score methodology was used in the adjusted analyses. Adjusted hazard ratio (HR) for the composite of death, MI, or repeat revascularization at 1 year was higher in IR than CR: 2.12 (95% confidence interval [CI]: 1.98 to 2.28; p < 0.0001). Adjusted HR for death and the combination of death/MI were 1.29 (95% CI: 1.12 to 1.49; p = 0.0005) and 1.42 (95% CI: 1.30 to 1.56; p < 0.0001), respectively.

Conclusions

Incomplete revascularization at the time of hospital discharge in patients with multivessel disease undergoing PCI is associated with a high risk of recurrent 1-year adverse cardiac events.