Assessment of the antiviral capacity of primary natural killer cells by optimized in vitro quantification of HIV-1 replication
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- 作者：Xuan Hea ; b ; 1 ; hexuan09@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Camille R. Simoneaua ; 1 ; csimoneau@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Mitchell E. Granoffa ; mitchell.granoff@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sebastian Lunemannc ; sebastian.lunemann@hpi.uni-hamburg.de" class="auth_mail" title="E-mail the corresponding author ; Anne-Sophie Dugasta ; adugast@merrimack.com" class="auth_mail" title="E-mail the corresponding author ; Yiming Shaob ; yshao@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Marcus Altfelda ; c ; marcus.altfeld@hpi.uni-hamburg.de" class="auth_mail" title="E-mail the corresponding author ; Christian Kö ; rnera ; c ; christian.koerner@hpi.uni-hamburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：HIV-1 ; Natural killer cell ; CD4+ T cell ; HIV-1 p24 ELISA ; HIV-1 RNA
- 刊名：Journal of Immunological Methods
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：434
- 期：Complete
- 页码：53-60
- 全文大小：1039 K
文摘
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We developed a standardized assay to assess the antiviral capacity of NK cells.
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NK cells from different donors differentially inhibit HIV-1 replication in vitro.
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HIV-1 RNA is a sensitive marker for HIV-1 replication in this in vitro assay.