Noviose mimics of the coumarin inhibitors of gyrase B
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- 作者：Musicki ; Branislav ; Periers ; Anne-Marie ; Piombo ; Laurent ; Laurin ; Patrick ; Klich ; Michel ; Dupuis-Hamelin ; Claudine ; et. al.
- 关键词：antibiotics ; coumarin ; noviose ; structure&ndash ; activity
- 刊名：Tetrahedron Letters
- 出版年：2003
- 出版时间：December 22, 2003
- 年：2003
- 卷：44
- 期：5
- 页码：9259-9262
- 全文大小：226 K
文摘
The design, synthesis, and biological activity in vitro of modified coumarin inhibitors of gyrase B are presented. Noviose, the sugar portion of coumarin antibiotics, was replaced by simplified mimics, a 5′,5′-dimethylcyclohexane or piperidine.