- 作者：Mark J. Niciua ; 1 ; mark.niciu@nih.gov" class="auth_mail" title="E-mail the corresponding author ; Chadi G. Abdallahb ; c ; 1 ; Lisa R. Fentond ; Madonna K. Fasulab ; Anne Blackd ; George M. Andersone ; Gerard Sanacorab
- 关键词：BDI ; Beck Depression Inventory ; ELL ; Early Life Parental Separation or Loss (as detected by the Klein Loss Scale) ; ELTI ; Early Life Trauma Inventory ; GPELS ; Global Perceived Early Life Stress ; HAM-A ; Hamilton Anxiety Rating Scale ; HDRS24 ; 24-item Hamilton Depression Rating Scale ; MDE ; Major Depressive Episode
- 刊名：Journal of Affective Disorders
- 出版年：2015
- 出版时间：15 November 2015
- 年：2015
- 卷：187
- 期：Complete
- 页码：241-244
- 全文大小：289 K
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Preliminary studies suggest that early life stress/trauma and excessive hypothalamic-pituitary-adrenal axis activity correlates with antidepressant response to cognitive-behavioral therapy (CBT) in major depressive disorder.
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Stress-related measures were correlated with antidepressant response to a 12-week course of once-weekly CBT in 50 currently depressed MDD outpatients.
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As a measure of baseline hypothalamic-pituitary-adrenal axis activity, 24-hour urinary cortisol levels did not correlate with CBT’s antidepressant efficacy.
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A personal history of early life parental loss or separation survived correction for multiple comparisons as a positive predictor of CBT response.
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Other forms of early life stress/trauma and perceived early life stress did not correlate with CBT’s antidepressant efficacy.