A mild, one-pot synthesis of disubstituted benzimidazoles from 2-nitroanilines

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• 作者：Keith R. Hornberger ; George M. Adjabeng ; Hamilton D. Dickson and Ronda G. Davis-Ward
• 关键词：Benzimidazoles ; Hydrogenation ; Cyclocondensation
• 刊名：Tetrahedron Letters
• 出版年：2006
• 出版时间：24 July 2006
• 年：2006
• 卷：47
• 期：30
• 页码：5359-5361
• 全文大小：87 K

文摘

A one-pot synthesis of disubstituted benzimidazoles from 2-nitroanilines is described. Hydrogenation of N-substituted 2-nitroanilines with palladium on carbon as catalyst in the presence of trimethyl orthoformate and catalytic pyridinium p-toluenesulfonate (PPTS) at room temperature provided good to excellent yields of the corresponding disubstituted benzimidazoles.