Retrospective cohort study utilizing a population-based dataset from Florida (1998-2007, n = 1,564,038). The primary outcomes were low birthweight (LBW), very low birthweight (VLBW), preterm birth (PTB), very preterm birth (VPTB) and small for gestational age (SGA). We used propensity scores to match infants with hemoglobinopathy to those without hemoglobinopathy on selected variables. To approximate relative risks, we generated adjusted odds ratios (AOR) and 95 % confidence intervals (CI) from logistic regression models and accounted for the matched design using generalized estimating equations framework.
Infants with SCD or thalassemia had a heightened risk for LBW (AOR = 1.58, 95 % CI: 1.29-1.93), VLBW (AOR = 3.01, 95 % CI: 2.12-4.25), PTB (AOR = 1.36, 95 % CI: 1.12-1.65), VPTB (AOR = 2.70, 95 % CI: 1.93-3.78), and neurological conditions (AOR = 2.04, 95 % CI: 1.48-2.81) compared to infants without hemoglobinopathy.
Infants with SCD or thalassemia experience considerably higher risks for multiple infant morbidities. Our findings are potentially important in prenatal counseling, as well as for targeted care of affected pregnancies in the prenatal period.