Selective IgA deficiency in early life: Association to infections and allergic diseases during childhood

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• 作者：Magdalena Janzi ; Inger Kull ; Ronald Sj&#xf6 ; berg ; Jinghong Wan ; Erik Melé ; n ; Narges Bayat ; Eva Ö ; stblom ; Qiang Pan-Hammarstr&#xf6 ; m ; Peter Nilsson ; Lennart Hammarstr&#xf6 ; m
• 关键词：Selective IgA deficiency ; Allergic diseases ; Infections ; Children ; BAMSE ; Serum microarrays
• 刊名：Clinical Immunology
• 出版年：2009
• 出版时间：October 2009
• 年：2009
• 卷：133
• 期：1
• 页码：78-85
• 全文大小：160 K

文摘

Selective IgA deficiency in early life is quite common in Caucasian populations, but it is unclear whether it increases the risk of infections and allergic diseases during childhood. Serum IgA levels were measured in 2423 children at 4 years of age in a Swedish population based birth cohort (BAMSE). Parental questionnaires were repeatedly sent out during the child's first 8 years of life, collecting information about infections and allergic diseases. 14 children (1:173) were found to be IgA deficient at 4 years of age. These children had an increased risk of pseudocroup at year 1 (p < 0.01) and food hypersensitivity at year 4 (p < 0.05) as compared to IgA sufficient children. No increased risk was observed in the partial IgA deficiency group. The findings suggest that selective IgA deficiency may increase the risk of parentally reported pseudocroup and food hypersensitivity during early childhood.